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A migraine is a severe headache that lasts for hours or days, often accompanied by disturbance of vision and nausea and vomiting. The attacks usually re-occur and can be brought on by stress, certain types of food, bright lights, loud noise and even strong smells. About 20% of the popluation has experienced a migraine attack and women are more likely to experience them. A person's first attack usually happens before age 20, and rarely after age 50.

Drugs can either be used to prevent long-term re-occurance, to cut short attacks, or for pain relief once an attack has started. 10-20% of sufferers get no relief from these drugs and many more get incomplete relief or suffer serious side effects.

Cannabis was highly regarded as a treatment for migraine in the 19th century. Dr J.B. Mattison wrote in 1891 that the treating migraine was the most important use of cannabis. Reviewing his own and earlier physicians' experiences, he concluded that cannabis not only blocks the pain, but prevents attacks. In 1913 William Osler expressed his agreement, saying that cannabis was probably the most satisfactory remedy for migraine. Yet there is little mention of the effect of cannabis on migraine in 20th century medical literature.

Individuals have experimented with cannabis however. They report that smoking a little amount of cannabis just as the early-warning signs of an attack (such as flickering vision) appear will prevent the attack from continuing. This may just be another analgesic effect of cannabis (combined with its anti-nausea effect), or it may be actually affecting the unknown biochemistry of the migraine in some manner.

Patients' testimonies

The medical testimonies database contains 19 testimonies from cannabis users with migraine .

David Mon 01 Dec 2014
Stuart Mon 01 Dec 2014
Lance Mon 31 Oct 2011
Willy Wed 07 Dec 2011
Anonymous Wed 09 Dec 2009
karl heydenrych Sun 09 Dec 2007
Anne Wade Thu 06 Dec 2007
Anonymous Fri 08 Dec 2006
Anonymous Mon 04 Dec 2006
Asher Sun 03 Dec 2006
Anonymous Mon 31 Oct 2005
Anonymous Thu 08 Dec 2005
Herbus Gerbus Wed 07 Dec 2005
Anonymous Mon 06 Dec 2004
Lawrence G. Mon 01 Dec 2003
Tom Sat 02 Nov 2002
Tracey Currey Sun 09 Dec 2001
Carol Miller Thu 07 Dec 2000
Terwur Thu 07 Dec 2000

For the complete collection of testimonies from medical users of cannabis, see our medical testimony database.

Do you find that cannabis helps you with this, or any other, medical condition? If so, please tell us about how it benefits you via this form. Anonymous submissions welcome!

Scientific evidence

The effect of cannabis on migraine could be an analgesic or anti-emetic effect - the evidence for these has been discussed elsewhere. There may also be a specific effect on migraines. Migraine attacks may be related to the neurotransmitter serotonin. Certainly, several of the more modern drugs that are currently prescribed to treat migraines work through the mechanism of affecting serotonin.

In 1985 Volfe et al. reported that THC inhibited the release of serotonin from the blood of migraine sufferers during an attack (but not at other times). This could be a clue to future research, which is obviously needed.

Russo (1998) reviewed the usage of cannabis for migraine treatment. The lack of clinical data is unhelpful, but he did conclude that 'cannabis...presents the hypothetical potential for quick, effective, parental treatment of acute migraine', Russo also noted both that many sufferers are not helped adequately by current medications, and that cannabis is a 'far safer alternative' to many currently prescribed anti-migraine drugs.

There is some weak anatomical evidence that cannabis could play some part in migraine treatment. There is a dense concentration of cannabinoid receptors in the periaqueductal gray part of the human brain. Goadsby et al (1991) found that this area of the brain suppresses pain, and is thought to be involved in the creation of a migraine attack.


Goadsby PJ, Gundlach AL. (1991) Localization of [3H]-dihydroergotamine binding sites in the cat central nervous system: Relevance to migraine. Annals of Neurology 29:91-, 94.

Mattison J.B. (1891) Cannabis indica as an anodyne and hypnotic. St Louis Medical Surgical Journal 61: 266

Osler W. (1913) The principles and practice of medicine 8th ed. (New York: Appleton) p1089

Russo E. (1998) Cannabis for Migraine Treatment: The Once and Future Prescription?: An Historical and Scientific Review. Pain 76

Volfe Z., Dvilansky A. and Nathan I. (1985) Cannabinoids block release of serotonin from platelets induced by plasma from migraine patients. International Journal of Clinical and Pharmacological Research 5: 243-246.

For a large collection of research materials, see our research page.

Other information has a comprehensive set of information about migraines in general, with several links, details about medicines and a discussion area.
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