medical testimonies database contains 19 testimonies from cannabis users with migraine
the complete collection of testimonies from medical users of cannabis, see our
medical testimony database.
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effect of cannabis on migraine could be an analgesic or anti-emetic effect - the
evidence for these has been discussed elsewhere. There may also be a specific
effect on migraines. Migraine attacks may be related to the neurotransmitter serotonin.
Certainly, several of the more modern drugs that are currently prescribed to treat
migraines work through the mechanism of affecting serotonin.
In 1985 Volfe et al. reported that THC inhibited the release of serotonin from
the blood of migraine sufferers during an attack (but not at other times). This
could be a clue to future research, which is obviously needed.
(1998) reviewed the usage of cannabis for migraine treatment. The lack of clinical
data is unhelpful, but he did conclude that 'cannabis...presents the hypothetical
potential for quick, effective, parental treatment of acute migraine', Russo also
noted both that many sufferers are not helped adequately by current medications,
and that cannabis is a 'far safer alternative' to many currently prescribed anti-migraine
is some weak anatomical evidence that cannabis could play some part in migraine
treatment. There is a dense concentration of cannabinoid receptors in the periaqueductal
gray part of the human brain. Goadsby et al (1991) found that this area of the
brain suppresses pain, and is thought to be involved in the creation of a migraine
PJ, Gundlach AL. (1991) Localization of [3H]-dihydroergotamine binding sites in
the cat central nervous system: Relevance to migraine. Annals of Neurology
J.B. (1891) Cannabis indica as an anodyne and hypnotic. St Louis Medical Surgical
Journal 61: 266
Osler W. (1913) The principles and practice of medicine 8th ed. (New York:
E. (1998) Cannabis for Migraine Treatment: The Once and Future Prescription?:
An Historical and Scientific Review. Pain 76
Volfe Z., Dvilansky A. and Nathan I. (1985) Cannabinoids block release of serotonin
from platelets induced by plasma from migraine patients. International Journal
of Clinical and Pharmacological Research 5: 243-246.
has a comprehensive set of information about migraines in general, with several
links, details about medicines and a discussion area.
a large collection of research materials, see our research