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Effects of frequent marijuana use on brain tissue volume and composition

by Robert I. Block et al, NeuroReport, Vol. 11, Issue 3, pp 491-496 (abstract only)

RECEIVED: 10 November 1999

ACCEPTED: 3 December 1999

AUTHOR: Robert I. Block*, Daniel S. O'Leary~, James C. Ehrhardt±, Jean C. Augustinack§, M. M. Ghoneim¶, Stephan Arndt**, James A. Hall~~

Full paper here, not on public access.

ADDRESS: *Department of Anesthesia, Westlawn Building, Room 5140, University of Iowa, Iowa City, IA 52242-1100, USA; ~Department of Psychiatry, University of Iowa, Iowa City, IA 52242-1100, USA; ±Department of Radiology, University of Iowa, Iowa City, IA 52242-1100, USA; §Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA 52242-1100, USA; ¶Department of Anesthesia, Westlawn Building, Room 5140, University of Iowa, Iowa City, IA 52242-1100, USA; **Department of Psychiatry, University of Iowa, Iowa City, IA 52242-1100, USA; ~~School of Social Work, University of Iowa, Iowa City, IA 52242-1100, USA

To investigate CNS effects of frequent marijuana use, brain tissue volume and composition were measured using magnetic resonance imaging (MRI) in 18 current, frequent, young adult marijuana users and 13 comparable, non-using controls. Automated image analysis techniques were used to measure global and regional brain volumes, including, for most regions, separate measures of gray and white matter. The marijuana users showed no evidence of cerebral atrophy or global or regional changes in tissue volumes. Volumes of ventricular CSF were not higher in marijuana users than controls, but were, in fact, lower. There were no clinically significant abnormalities in any subject's MRI. Sex differences were detected in several global volume measures. NeuroReport 11:491-496 © 2000 Lippincott Williams & Wilkins.

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