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Use and Lung Cancer: Results of a Case-Control Study Abstract
from the American Thoracic
Society International Conference 2006. [8:15
am] Marijuana Use and Lung Cancer: Results of a Case-Control Study, [Publication
Page: A777]
D.P. Tashkin, M.D., Z.-F. Zhang, M.D.,
Ph, S. Greenland, Dr.P.H., W. Cozen, D.O., T.M. Mack, M.D., H. Morgenstern, Ph.D.,
Los Angeles, CA, Ann Arbor, MI
Introduction: Marijuana
(MJ) smoke contains several known carcinogens, & heavy habitual use can produce
accelerated malignant change in lung explants & pre-malignant histopathologic
& molecular changes in bronchial biopsies. While results of experimental animal
and epidemiologic studies have been mixed, most epidemiologic studies have been
limited by small numbers of heavy long-term MJ users and by sources of possible
bias.
Methods: We therefore assessed possible associations between
MJ use - including heavy long-term use - and the risk of lung cancer (ca) in middle-aged
adults living in Los Angeles County (LAC). A population-based case-control study
was conducted by identifying ca cases, ages 18-59, through rapid ascertainment
by the LAC Cancer Surveillance Program. Controls were matched to cases on age,
gender & neighborhood. Personal interviews were completed in 611 lung ca cases
& 1040 controls. Data were collected on lifetime use of MJ (measured in joint-yrs
[j-yrs]; 1 j-yr=365 joints), tobacco (tob), alcohol & other drugs, SES, diet,
occupation & family hx of ca. Logistic regression was used to estimate the
effect of MJ use on lung ca risk, adjusting for age, gender, race/ethnicity, education
& cumulative tob smoking & alcohol use.
Results:
| MJ
use, j-yrs | #
cases | #
controls | OR*
(95% C.I.) | p
value | | 0 | 302 | 474 | 1 | - |
| >0-<1 | 162 | 313 | .66
(.49-.90) | 0.008 |
| 1-<10 | 64 | 127 | .71
(.46-.90) | 0.083 |
| 10-<30 | 30 | 544 | .60
(.32-1.1) | 0.077 |
| 30-<60 | 24 | 23 | .94
(.46-1.9) | 0.086 |
| 60 | 28 | 35 | .56
(.29-1.1) | 0.073 |
*Adjusted
for age, sex, race, educational level tobacco
Conclusion: We did
not observe a positive association of MJ use- even heavy long-term use - with
lung ca, controlling for tob smoking and other potential confounders.
Session Info: [**] Mini-Symposium, [D12] LUNG CANCER: 2006
Session Time: 8:15 AM - 11:00 AM
Presentation Date: Wednesday,
May 24, 2006
Presentation Time: 8:15 AM
Room: Marriott Hall
1-2 (Marriott Pavilion), San Diego Marriott Hotel and Marina |
