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Marijuana Use and Lung Cancer: Results of a Case-Control Study

Abstract from the American Thoracic Society International Conference 2006.

[8:15 am] Marijuana Use and Lung Cancer: Results of a Case-Control Study, [Publication Page: A777]

D.P. Tashkin, M.D., Z.-F. Zhang, M.D., Ph, S. Greenland, Dr.P.H., W. Cozen, D.O., T.M. Mack, M.D., H. Morgenstern, Ph.D., Los Angeles, CA, Ann Arbor, MI

Introduction: Marijuana (MJ) smoke contains several known carcinogens, & heavy habitual use can produce accelerated malignant change in lung explants & pre-malignant histopathologic & molecular changes in bronchial biopsies. While results of experimental animal and epidemiologic studies have been mixed, most epidemiologic studies have been limited by small numbers of heavy long-term MJ users and by sources of possible bias.
Methods: We therefore assessed possible associations between MJ use - including heavy long-term use - and the risk of lung cancer (ca) in middle-aged adults living in Los Angeles County (LAC). A population-based case-control study was conducted by identifying ca cases, ages 18-59, through rapid ascertainment by the LAC Cancer Surveillance Program. Controls were matched to cases on age, gender & neighborhood. Personal interviews were completed in 611 lung ca cases & 1040 controls. Data were collected on lifetime use of MJ (measured in joint-yrs [j-yrs]; 1 j-yr=365 joints), tobacco (tob), alcohol & other drugs, SES, diet, occupation & family hx of ca. Logistic regression was used to estimate the effect of MJ use on lung ca risk, adjusting for age, gender, race/ethnicity, education & cumulative tob smoking & alcohol use.

Results:

MJ use, j-yrs# cases# controlsOR* (95% C.I.)p value
03024741-
>0-<1162313.66 (.49-.90)0.008
1-<1064127.71 (.46-.90)0.083
10-<3030544.60 (.32-1.1)0.077
30-<602423.94 (.46-1.9)0.086
602835.56 (.29-1.1)0.073
*Adjusted for age, sex, race, educational level tobacco

Conclusion: We did not observe a positive association of MJ use- even heavy long-term use - with lung ca, controlling for tob smoking and other potential confounders.

Session Info: [**] Mini-Symposium, [D12] LUNG CANCER: 2006
Session Time: 8:15 AM - 11:00 AM
Presentation Date: Wednesday, May 24, 2006
Presentation Time: 8:15 AM
Room: Marriott Hall 1-2 (Marriott Pavilion), San Diego Marriott Hotel and Marina

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