Marijuana v.s. Tobacco smoke compositions

From: Institute of Medicine, Marijuana and Health, Washington,D.C.
National Academy Press, 1988

Table 3 : Marijuana and Tobacco Reference Cigarette Analysis of Mainstream Smoke (pg 17)

A.Cigarettes
Units Marijuana Tobacco
(85mm) (85mm)
Average Weight (mg) 1115 1110
Mositure (%) 10.3 11.1
Pressure Drop cm 14.7 7.2
Static Burning rate mg/s 0.88 0.80
Puff Number 10.7 11.1

B.Mainstream Smoke
I. Gas Phase Units Marijuana Tobacco
Carbon Monoxide % 3.99 4.58
mg 17.6 20.2
Carbon Dioxide % 8.27 9.38
mg 57.3 65.0
Ammonia mcg 228 199
HCN mcg 532 498
Cyanogen (CN)2 mcg 19 20
Isoprene mcg 83 310
Acetaldehyde mcg 1200 980
Acetone mcg 443 578
Acrolein mcg 92 85
Acetonitrilebenzene mcg 132 123
Benzene mcg 76 67
Toluene mcg 112 108
Vinyl chloride ng 5.4 12.4
Dimethylnitrosamine ng 75 84
Methylethylnitrosamine ng 27 30
pH, third puff 6.56 6.14
fifth puff 6.57 6.15
seventh puff 6.58 6.14
ninth puff 6.56 6.10
tenth puff 6.58 6.02

II. Particulate phase Units Marijuana Tobacco
Tl particulate - dry mg 22.7 39.0
Phenol mcg 76.8 138.5
o-Cresol mcg 17.9 24
m- and p-Cresol mcg 54.4 65
Dimethylphenol mcg 6.8 14.4
Catechol mcg 188 328
Cannbidiol mcg 190
D9 THC mcg 820
Cannabinol mcg 400
Nicotine mcg 2850
N-Nitrosonornicotine ng 390
Naphthalene mcg 3.0 1.2
1-Methylnaphthalene mcg 6.1 3.65
2-Methylnaphthalese mcg 3.6 1.4
Benz(a)anthracene ng 75 43
Benzo(a)pyrene ng 31 21.1

Sources cited by the Institute of Medicine:

Hofmann, D., Brunnemann, K.D.,Gori,G.B. and Wynder, E.L. On the carcinogenicity of marijuana smoke, pp 63-81. In Runeckles, V.C. (ed) Recent Advances in Phytochemistry New York: Plenum Publishing Corp., 1975.

Hoffmann, D., Patrianakos, C., Brunneman, K.D., et al. Chromatographic determination of vinyl chloride in tobacco smoke. Anal Chem 48:47-50, 1976.

Brunnemann,K.D., Lee, H.C., and Hoffmann, D. Chemical studies on tobacco smoke. XLVII. On the quantitative analysis of catechols and their reduction. Anal. Lett. 9:939-955, 1976.

Brunnemann, K.D., Yu, L., and Hoffmann, D. Chemical Studies on tobacco somke. XLIX. Gas chromotographic determination of hydrogen cyanide and cynogen in tobacco smoke. J Anal. Toxicol. 1:38-42, 1977.


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