Marijuana Use and Lung Cancer: Results of a Case-Control Study
Abstract from the American Thoracic Society International Conference 2006
Abstract from the American Thoracic Society International Conference 2006.
am] Marijuana Use and Lung Cancer: Results of a Case-Control Study, [Publication
D.P. Tashkin, M.D., Z.-F. Zhang, M.D., Ph, S. Greenland, Dr.P.H., W. Cozen, D.O., T.M. Mack, M.D., H. Morgenstern, Ph.D., Los Angeles, CA, Ann Arbor, MI
Introduction: Marijuana (MJ) smoke contains several known carcinogens, & heavy habitual use can produce accelerated malignant change in lung explants & pre-malignant histopathologic & molecular changes in bronchial biopsies. While results of experimental animal and epidemiologic studies have been mixed, most epidemiologic studies have been limited by small numbers of heavy long-term MJ users and by sources of possible bias.
Methods: We therefore assessed possible associations between MJ use - including heavy long-term use - and the risk of lung cancer (ca) in middle-aged adults living in Los Angeles County (LAC). A population-based case-control study was conducted by identifying ca cases, ages 18-59, through rapid ascertainment by the LAC Cancer Surveillance Program. Controls were matched to cases on age, gender & neighborhood. Personal interviews were completed in 611 lung ca cases & 1040 controls. Data were collected on lifetime use of MJ (measured in joint-yrs [j-yrs]; 1 j-yr=365 joints), tobacco (tob), alcohol & other drugs, SES, diet, occupation & family hx of ca. Logistic regression was used to estimate the effect of MJ use on lung ca risk, adjusting for age, gender, race/ethnicity, education & cumulative tob smoking & alcohol use.
|MJ use, j-yrs||# cases||# controls||OR* (95% C.I.)||p value|
Conclusion: We did not observe a positive association of MJ use- even heavy long-term use - with lung ca, controlling for tob smoking and other potential confounders.
Session Info: [**] Mini-Symposium, [D12] LUNG CANCER: 2006
Session Time: 8:15 AM - 11:00 AM
Presentation Date: Wednesday, May 24, 2006
Presentation Time: 8:15 AM
Room: Marriott Hall 1-2 (Marriott Pavilion), San Diego Marriott Hotel and Marina