to Wootton Report Index
Health OrganisationAppraisal of Cannabis type Dependence
Dependence of Cannabis (Marihuana) Type
is not known with absolute certainty which of the chemical structures that have
been isolated from Cannabis sativa L. is responsible for the typical cannabis
effects, but these can nevertheless be described as constituting an entity that
varies in degree according to the concentration of the active principle or principles
in the plant and the preparations obtained therefrom, and to the mode of application.
These effects are also producible by certain synthetic substances of similar chemical
the more prominent subjective effects of cannabis, for which it is taken
occasionally, periodically or chronically, are: hilarity, often without apparent
motivation; carelessness; loquacious euphoria, with increased sociability as a
result; distortion of sensation and perception especially of space and time with
the latter reinforcing psychic dependence and being valued under special circumstances;
impairment of judgment and memory; distortion of emotional responsiveness; irritability;
and confusion. Other effects, which appear especially after repeated administration
and as more experience is acquired by the user include; lowering of the sensory
threshold, especially for optical and acoustical stimuli, thereby resulting in
an intensified appreciation of works of art, paintings and of music; hallucinations,
illusions, and delusions that predispose to antisocial behaviour; anxiety and
aggressiveness as a possible result of the various intellectual and sensory derangements;
and sleep disturbances.
the psychomotor sphere, hypermotility occurs without impairment of coordination.
Among somatic effects, often persistent, are injection of the ciliary vessels
and oropharyngitis, chronic bronchitis and asthma; these conditions and hypoglycaemia,
with ensuing bulimia, are symptoms of intoxication, not of withdrawal.
the abuse of cannabis is periodic but, even during long and continuous administration,
no evidence of the development of physical dependence can be detected. There is,
in consequence no characteristic abstinence syndrome when use of the drug
administration of the drug is periodic or continuous, tolerance to its subjective
and psychomotor effects has not been demonstrated.
cannabis often attracts the mentally unstable and may precipitate temporary psychoses
in predisposed individuals, no unequivocal evidence is available that lasting
mental changes are produced.
dependence of the cannabis type is a state arising from chronic or periodic administration
of cannabis or cannabis substances (natural or synthetic) Its characteristics
to strong psychic dependence on account of the desired subjective effects.
(b) Absence of physical dependence, so that there is no characteristic abstinence
syndrome when the drug is discontinued.
(c) Little tendency to increase the
dose and no evidence of tolerance.
the individual, harm resulting from abuse of cannabis may include inertia, lethargy,
self-neglect, feeling of increased capability, with corresponding failure, and
precipation of psychotic episodes. Abuse of cannabis facilitates the association
with social groups and subcultures involved with more dangerous drugs, such as
opiates or barbiturates. Transition to the use of such drugs would be a consequence
of this association rather than an inherent effect of cannabis. The harm to society
derived from abuse of cannabis rests in the economic consequence of the impairment
of the individual's social functions and his enhanced proneness to a social and